{"product_id":"edubily-pure-citrullin-malat-kapseln","title":"PURE Citrulline Malate Capsules","description":"\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003e\u003cspan\u003e2.9 g r\u003c\/span\u003eof citrulline malate in practical capsule form\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eEfficient increase in arginine levels\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eVegan capsules with no unwanted additives\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003e\u003cspan\u003eNo caffeine or DMAA\u003c\/span\u003e\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003e\u003cspan\u003eWith silica as an anti-caking agent (production-related)\u003c\/span\u003e\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eLaboratory tested for heavy metals\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eContents: 300 capsules = 60 servings\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- more --\u003e\n\u003ch2\u003eThe amino acid citrulline\u003c\/h2\u003e\n\u003cp\u003eCitrulline belongs to the amino acids and was first isolated from watermelons – hence the name, derived from the Latin word for watermelon, \"citrullus\". The scientific description of this compound goes back to Japanese researchers at the beginning of the 20th century. Watermelons are still considered a natural source of citrulline today.\u003c\/p\u003e\n\u003cp class=\"\"\u003eIn human metabolism, citrulline plays a central role in the so-called urea cycle – the biochemical process through which the body excretes excess nitrogen in the form of urea.\u003c\/p\u003e\n\u003cp class=\"\"\u003eCitrulline is also produced as an intermediate during the formation of nitric oxide (NO) from the amino acid arginine. This process is controlled by the enzyme nitric oxide synthase. In the body, citrulline can be converted back into arginine via the urea cycle, making it indirectly available again for NO production.\u003c\/p\u003e\n\u003ch2\u003eCitrulline's effect on arginine levels?\u003c\/h2\u003e\n\u003cp\u003eStudies in animal models show that supplementation with citrulline can raise arginine levels in the blood more efficiently than direct intake of arginine itself. The reason: a large proportion of arginine is already broken down in the intestine before it reaches the bloodstream.\u003c\/p\u003e\n\u003cp class=\"\"\u003eCitrulline, on the other hand, is largely absorbed unchanged and then converted into arginine in the body – which in turn benefits the body's own nitric oxide synthesis.\u003c\/p\u003e\n\u003cp class=\"\"\u003eIn studies with mice, citrulline supplementation achieved higher arginine availability in the blood than direct arginine intake.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cem\u003e\"Citrulline supplementation is more efficient at increasing arginine availability than arginine supplementation itself in mice.\"\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan\u003e– \u003c\/span\u003e\u003c\/em\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5368575\/\"\u003eSource\u003c\/a\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch2\u003eWhy combine it with malate?\u003c\/h2\u003e\n\u003cp\u003eCitrulline malate is a special form in which citrulline is combined with malate – the salt form of malic acid. Malate is known from apples and also plays a role in the body's energy metabolism.\u003c\/p\u003e\n\u003cp class=\"\"\u003eThe combination of citrulline and malate was investigated in a \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12145119\/\"\u003ehuman study\u003c\/a\u003e published in the \u003cem\u003eBritish Journal of Sports Medicine\u003c\/em\u003e. Using magnetic resonance spectroscopy, it was shown that taking citrulline malate for 15 days leads to improved energy supply in the muscles.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp class=\"\"\u003e\u003cem\u003e\"The rate of oxidative ATP production in muscles during training and the rate of PCr recovery after training both increase in subjects who receive citrulline\/malate for 15 days. This positive effect of citrulline\/malate at the oxidative level may be mediated by malate, an intermediate product of the tricarboxylic acid cycle.\"\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp class=\"\"\u003eSpecifically, it was found that both mitochondrial ATP production during physical activity and phosphocreatine regeneration after exertion were increased. ATP (adenosine triphosphate) is the most important energy source for muscle contractions and physical performance.\u003c\/p\u003e\n\u003cp class=\"\"\u003eScientists assume that this effect is not due to citrulline alone, but also largely to malate. Malate is an intermediate product of the citric acid cycle – a central part of aerobic energy production. There, it is converted into oxaloacetate, a crucial regulator of the speed of ATP synthesis using oxygen.\u003c\/p\u003e\n\u003cblockquote\u003e\u003c\/blockquote\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cem\u003eMalate is dehydrogenated to oxaloacetate in the citric acid cycle, the concentration of which is one of the most important control variables for the rate of aerobic ATP production.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003eCombining citrulline with malate not only improves blood flow, but also promotes ATP synthesis in the muscles. \u003c\/p\u003e\n\u003ch2\u003eCitrulline malate for athletes?\u003c\/h2\u003e\n\u003cp\u003eCitrulline malate is regularly studied for performance support in strength and endurance sports. So far, the results are not consistent – clear and generally applicable intake recommendations, such as for creatine, cannot currently be derived.\u003c\/p\u003e\n\u003cp class=\"\"\u003eNevertheless, citrulline malate is considered a promising substance for high-intensity training and competition demands.\u003c\/p\u003e\n\u003cp class=\"\"\u003eIndividual studies suggest that taking citrulline malate before athletic exertion – for example in tennis – may improve performance. It should be noted that these results were obtained under controlled laboratory conditions. Whether these effects can be transferred one-to-one to real competition situations remains the subject of further research.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cem\u003e\"These data suggest that taking citrulline malate before competition may improve tennis players' performance. However, this study used a controlled laboratory environment, so investigating its direct application to performance on the tennis court should be considered.\"\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e–\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27017895\/\"\u003eSource of the 2016 RCT study\u003c\/a\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions \u0026amp; answers from Edubily\u003c\/h2\u003e\n\u003ch3\u003eWho should not take citrulline?\u003c\/h3\u003e\n\u003cp\u003ePeople who have problems with the cardiovascular system or have a condition in this area should discuss taking citrulline malate with their doctor.\u003c\/p\u003e\n\u003cp\u003ePeople with rheumatoid arthritis may have an increased risk of antibodies against citrullinated proteins (ACPA), which can lead to autoimmune reactions. People with elevated glucose levels should also be cautious, as they already have elevated citrulline levels. People with low blood pressure should also avoid citrulline, as it can lower it further.\u003c\/p\u003e\n\u003ch3\u003eWhy is no arginine included?\u003c\/h3\u003e\n\u003cp\u003eCitrulline is enough – it is converted into arginine in the body and at the same time inhibits arginine breakdown. This keeps arginine levels high for longer than with direct arginine intake.\u003c\/p\u003e\n\u003ch3\u003eWhy not simply take arginine instead of citrulline?\u003c\/h3\u003e\n\u003cp\u003eCitrulline is absorbed more efficiently by the body and remains active for longer. This can allow it to have a more sustained effect than pure arginine.\u003c\/p\u003e\n\u003ch3\u003eIs the product vegan?\u003c\/h3\u003e\n\u003cp\u003eYes, the PURE Citrulline Malate capsules are 100% vegan, including the capsule shell made from HPMC.\u003c\/p\u003e\n\u003ch3\u003eWhat side effects does citrulline malate have?\u003c\/h3\u003e\n\u003cp\u003eTaking it on an empty stomach may cause mild nausea. It is recommended not to take citrulline malate on an empty stomach.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eNutritional values\u003c\/h2\u003e\n\u003ctable class=\"NFTable\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003e\u003cstrong\u003eContent\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth\u003e\n\u003cstrong\u003eper serving\u003c\/strong\u003e\u003cbr\u003e(= 5 capsules)\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eL-citrulline malate\u003c\/td\u003e\n\u003ctd\u003e2,9 g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eof which L-citrulline\u003c\/td\u003e\n\u003ctd\u003e2 g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eIngredients\u003c\/h2\u003e\n\u003cp\u003eL-citrulline malate, hydroxypropyl methylcellulose (capsule shell), anti-caking agent silicon dioxide.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommended use: \u003c\/strong\u003eTake 5 capsules daily, unchewed, either together or in several servings with plenty of liquid.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNotes: \u003c\/strong\u003eDo not exceed the stated recommended daily dose. Keep out of reach of small children. This product is not a substitute for a balanced and varied diet or a healthy lifestyle. Store in a cool, dry and dark place.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0527\/1722\/4107\/files\/Ikons_Edubilys_Vorteile.png?v=1738593544\"\u003e\u003c\/p\u003e\n\u003ch2\u003eQuality \u0026amp; safety to the highest standard\u003c\/h2\u003e\n\u003cp\u003eEdubily places great importance on developing and manufacturing products based on a scientifically sound foundation. Its production takes place at experienced partners in Germany and Austria, which are regularly inspected without prior notice and certified according to IFS Food and HACCP. This means Edubily meets strict hygiene and safety requirements. In addition, all products are tested again in independent laboratories for factors such as heavy metals, nutrient levels and possible contaminants. Edubily's aim is not simply to offer just any dietary supplements, but safe and effective ones that benefit health and well-being through well-thought-out formulations and continuous development. This lets fitness athletes and health-conscious people be confident they are getting a high-quality, responsibly designed product.\u003c\/p\u003e","brand":"edubily","offers":[{"title":"Default Title","offer_id":54964342522242,"sku":"3510.PCK.ED","price":51.9,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0527\/1722\/4107\/files\/edubily-pure-citrullin-malat-kapseln-citrullin-1144423282.webp?v=1741831027","url":"https:\/\/haghpowered.com\/en\/products\/edubily-pure-citrullin-malat-capsules","provider":"HighPowered Fitness","version":"1.0","type":"link"}